Transcend Vivoscope will launch SUPERNOVA-600, a turnkey miniature two-photon imaging system, at the ongoing Neuroscience 2024 conference in Chicago, Illinois.

SUPERNOVA-600 is an advanced miniature two-photon microscopy (mTPM) solution.

The miniature microscope is said to allow fast, high-resolution, multi-plane calcium imaging for neurological studies in freely moving animals.

It features poLight’s TLens tunable optics that enable real-time optimal microscopic in vivo imaging of the brain’s neuronal and cellular activities.

According to poLight, TLens replicates the human eye experience for autofocus in devices like smartphones, wearables, barcode scanners, machine vision systems, and medical equipment.

poLight CEO Oyvind Isaksen said: “Following the Kavli Institute’s use of TLens in their miniature two-photon innovation and subsequent Nobel Prize, we have seen strong interest in this unique device from many research groups around the world.

“We are excited to see another commercial player supplying the tools and resources to accelerate the deployment of mTPM systems, and we look forward to a long-term relationship with Transcend Vivoscope.”

SUPERNOVA-600 is designed to enhance research in cognition, drug development, and diseases like Alzheimer’s, epilepsy, and Parkinson’s.

Last year, Transcend Vivoscope introduced SUPERNOVA-100, a compact mTPM imaging system.

In April, the Transcend Vivoscope installed and commissioned the SUPERNOVA-100 at Seoul National University College of Medicine in South Korea.

The SUPERNOVA family also includes SUPERNOVA-3000, a miniature three-photon microscope.

Founded in 2016, Transcend Vivoscope specialises in miniature two-photon microscopy technology, providing advanced imaging solutions for neuroscience researchers globally.

In 2017, the biomedical imaging firm captured clear images of brain cells and subcellular structures in free-behaving mice.

Since then, the company has developed and commercialised a range of miniature two-photon microscopy systems for neuroscience.

Transcend Vivoscope R&D director Wu Runlong said: “The SUPERNOVA-600, our latest flagship product, offers flexible and diverse combination configurations.

“It allows for the real-time synchronisation of microscopic neuronal and synaptic activity with the overall information processing of the brain and individual behaviours, providing a panoramic analysis of connectomes and functional dynamic maps.”