Japanese photonics technology developer Hamamatsu Photonics has introduced a new cell analyser, CYTOQUBE (C15200-01RGBU) light-sheet microplate cytometer, designed for 3D cell screening assays.
CYTOQUBE is said to be a rapid and user-friendly system for measuring the size, shape, and function of individual cells within a population. It integrates light-sheet optics with advanced image analysis and an intuitive interface.
The device is engineered for detailed imaging of multi-well cell culture plates.
It uses a streamlined light-sheet microscopy setup and Hamamatsu Photonics’ proprietary Zyncscan image processing platform.
Using these technologies, CYTOQUBE captures 3D fluorescence images from each well of an entire microplate. This technology facilitates efficient cell size, shape, quantity, and colour/intensity assays.
CYTOQUBE’s light-sheet optical system simplifies 3D imaging. Conversely, its Zyncscan algorithms enhance image acquisition speed, provide 3D rendering, and improve signal-to-noise ratios by eliminating background fluorescence.
According to Hamamatsu, the North American subsidiary of Hamamatsu Photonics, the CYTOQUBE light-sheet microplate cytometer is suitable for the drug discovery industry.
The latest products offer 3D fluorescence imaging and accelerate the acquisition of live 3D cytology data.
By streamlining this process, the CYTOQUBE can enhance drug screening efficiency and enable new possibilities in cellular assays, benefiting the drug discovery pathway, Hamamatsu Photonics said.
Cells in the microplate are illuminated from below using light-sheet excitation, with XZ tomographic images captured by a scientific CMOS camera. The detection system is positioned at an angle relative to both the sample and the illumination, decoupling detection from illumination.
CYTOQUBE constructs a complete 3D fluorescence image in a single scan of the plate by continuously acquiring XZ tomographic images. The device does this while moving the microplate perpendicular to the light-sheet.
Additionally, the cell analyser’s software can simultaneously remove unwanted background fluorescence in real-time, enhancing image quality by reducing signal degradation.
In June the photonics technology developer introduced a new X-ray flat panel sensor. The device delivers real-time images for non-destructive testing (NDT) and digital radiography applications.
In May, the US Food and Drug Administration (FDA) allowed the use of Hamamatsu Photonics’ NanoZoomer S360MD Slide scanner with Indica Labs’ HALO AP Dx platform.
